Which technical change is best for addressing dissimilar tissue densities in radiography?

Using high-kilovoltage exposure factors is particularly effective for addressing dissimilar tissue densities in radiography because it enhances the penetration of X-rays through various tissue types. Different tissues in the body, such as fat and muscle, have different densities and atomic compositions. Higher energy X-rays produced by increased kilovoltage are more capable of passing through denser tissues while still providing adequate contrast for visualization. This allows for a clearer image that can more effectively differentiate between structures that vary in density.

In contrast, other options do not optimize the penetration of X-rays in the same way. Short exposure times primarily focus on reducing motion blur rather than addressing the inherent differences in tissue densities. The use of a high-ratio grid can help reduce scatter radiation and improve image contrast, but it does not directly enhance the ability of X-rays to penetrate denser tissues. Lastly, increasing milliampere-seconds can increase the overall exposure, which may help with image quality but does not specifically adjust for differences in tissue density. High kilovoltage settings thus stand out as the best technical change for this scenario.